Melatonin Linked to Heart Failure Risk
Analysis based on 16 articles · First reported Nov 03, 2025 · Last updated Nov 04, 2025
The research linking long-term Melatonin use to heart failure could negatively impact the market for Melatonin supplements, potentially leading to decreased sales and increased scrutiny from regulatory bodies like the United States — Food and Drug Administration. It may also spur further research and development in alternative sleep aids and cardiovascular health monitoring.
New research presented by the American Heart Association suggests a significant link between long-term use of Melatonin and an increased risk of heart failure, hospitalization, and early death in adults with insomnia. The study, led by Ekenedilichukwu Nnadi, analyzed health records of over 130,000 adults, finding that those who used Melatonin for at least a year were nearly twice as likely to develop heart failure. Experts like Nishant Shah and Martha Gulati caution that the study shows a correlation, not causation, but emphasize the need for further research into the safety of supplements, especially given that Melatonin is not regulated by the United States — Food and Drug Administration. Marie-Pierre St-Onge advises against chronic use without medical guidance. This event highlights potential health risks associated with a widely used over-the-counter supplement.
Set up alerts, explore entity relationships, search across thousands of events, and build custom intelligence feeds.
Open Dashboard