CAR T-cell Therapy Heals Aging Guts

Researchers at Cold Spring Harbor Laboratory, led by Corina Amor Vegas, Semir Beyaz, and Onur Eskiocak, have discovered a novel application for CAR T-cell therapy to help aging intestines heal themselves. By targeting senescent cells that accumulate over time, the treatment boosted gut regeneration, reduced inflammation, and improved nutrient absorption in mice. The therapy also protected the intestine from radiation damage, with benefits lasting up to a year. Early results in human intestinal and colorectal cells suggest strong therapeutic potential for older adults and cancer patients suffering from conditions like leaky gut syndrome. This breakthrough builds on earlier research into cellular senescence and could pave the way for future clinical trials.