MeiraGTx AAV-hAQP1 3-Year Data
Analysis based on 6 articles · First reported Apr 14, 2026 · Last updated Apr 16, 2026
The positive three-year data for AAV-hAQP1 from MeiraGTx's Phase 1 AQUAx study is expected to significantly boost investor confidence in MeiraGTx, potentially leading to an increase in its stock price. This development highlights a promising new treatment for radiation-induced xerostomia, opening up a meaningful commercial opportunity for MeiraGTx in the genetic medicines market.
MeiraGTx announced positive three-year data from its completed Phase 1 AQUAx study of AAV-hAQP1, an investigational gene therapy for the treatment of grade 2/3 late radiation-induced xerostomia (RIX). The data showed clinically meaningful improvements in xerostomia symptoms and increases in unstimulated whole saliva flow rate, which were maintained for three years post-treatment. The treatment was also found to be safe and well-tolerated. Alexandria Forbes, CEO of MeiraGTx, highlighted the extraordinary durability and disease-modifying impact of the one-time treatment, emphasizing the significant unmet need and commercial potential for AAV-hAQP1. MeiraGTx hosted a conference call and webcast on April 16, 2026, to present these findings.
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