Vitamin D deficiency increases post-surgery pain
Analysis based on 7 articles · First reported May 19, 2026 · Last updated Jun 01, 2026
The study's findings could lead to increased demand for Vitamin D supplements as a preoperative intervention for breast cancer patients, potentially benefiting pharmaceutical and healthcare companies involved in vitamin production and distribution. It also highlights the potential to reduce reliance on opioid drugs like Fentanyl and Tramadol, which could impact the market for these pain medications.
A prospective observational study conducted at Fayoum University Hospital>>> in Egypt>>> found a significant association between Vitamin D deficiency and increased moderate to severe postoperative pain, as well as higher opioid consumption (Fentanyl and Tramadol) in breast cancer patients undergoing mastectomy. Patients with low Vitamin D levels were three times more likely to report moderate to severe pain and used substantially more Tramadol after surgery. The research, published in American Society of Regional Anesthesia and Pain Medicine>>> and reported by BMJ (company)>>>, suggests that preoperative Vitamin D supplementation could play a role in modulating postoperative pain and reducing opioid dependence, although further clinical trials are needed to establish causation.
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