Methylglyoxal links heart attacks to brain damage

A new study led by the University of Ottawa and the University of Ottawa, with Dr. Erik Suuronen>>> as senior author, has identified Methylglyoxal>>> (MG) as a key molecule linking heart attacks to neurological complications like depression, anxiety, and cognitive decline. MG surges in the bloodstream and accumulates in specific brain regions after a heart attack, triggering inflammation and cellular damage. This finding, published in Science Advances, supports the 'heart-brain axis' concept and suggests that MG-driven neuroinflammation contributes to long-term neurological risks. The research team has also developed a peptide therapeutic designed to trap Methylglyoxal>>>, which will soon be tested to protect the brain from damage and potentially reduce the risk of future cardiac events.