NAD+ Blood Levels Not Declining
Analysis based on 6 articles · First reported May 23, 2026 · Last updated Jun 04, 2026
The new research suggesting that blood levels of Nicotinamide adenine dinucleotide>>> do not decline with age could negatively impact the market for NAD+ supplements, affecting companies like Walgreens>>> and Walmart>>> that sell these products, and potentially leading to decreased sales for manufacturers like Altor BioScience>>>. This challenges the core marketing premise for a booming anti-aging supplement industry.
New research published in Nature Metabolism challenges the widely accepted belief that blood levels of Nicotinamide adenine dinucleotide>>> (NAD+) decline with age. This finding contradicts a central claim used to market NAD+ anti-aging supplements, which have been endorsed by celebrities and influencers such as Gwyneth Paltrow>>>, Kendall Jenner>>>, Hailey Bieber>>>, Andrew Huberman>>>, Bryan Johnson (businessman)>>>, and Gary Brecka>>>. The study, led by Riekelt Houtkooper>>> of Amsterdam University Medical Center>>>, analyzed blood samples from over 300 people and found no evidence of age-related decline in NAD+ blood levels, although supplementation could increase them. While some experts like Matt Kaeberlein>>> from the University of Washington believe this should prompt questioning of the 'dogma,' others like Joseph Baur>>> of the University of Pennsylvania and Andrew Shao>>> of Altor BioScience>>> argue that NAD+ decline in tissues (muscle, brain) is more relevant, despite acknowledging this research is preliminary. The findings suggest that the marketing of NAD+ supplements may have 'outpaced the actual data' and been 'oversimplified' to consumers, potentially impacting the supplement market.
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