PeproMene Bio PMB-CT01 Lymphoma Results
Analysis based on 7 articles · First reported May 28, 2026 · Last updated May 28, 2026
The positive clinical data for PMB-CT01 from PeproMene Bio could significantly impact the biotechnology and pharmaceutical markets by introducing a new, effective treatment for B-cell lymphomas, especially for patients who have failed prior therapies. This success could lead to increased investor interest in PeproMene Bio and similar CAR T-cell therapies, potentially driving up valuations in the sector.
PeproMene Bio announced updated clinical data from its Phase 1 study of PMB-CT01, a BAFF-R-targeted CAR T-cell therapy, at the 2026 Congress of the European Hematology Association. The study, focusing on relapsed/refractory B-cell non-Hodgkin lymphoma patients, including those who failed prior CD19 CAR T-cell therapy, showed a promising safety profile with no dose-limiting toxicities or severe cytokine release syndrome/neurotoxicity. Importantly, PMB-CT01 achieved a 78% complete response rate among nine patients, with durable responses lasting over 3 years and all responding patients achieving minimal residual disease-negative status. Larry W. Kwak, scientific founder of PeproMene Bio, highlighted the validation of BAFF-R as a novel target and the potential for outpatient use due to the favorable safety. The trial is expanding to include more patients with mantle cell lymphoma, large B-cell lymphoma, and follicular lymphoma.
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