Mayo Clinic maps meningioma behavior

Researchers at Mayo Clinic and Princess Margaret Cancer Centre have created one of the most detailed maps of meningioma, the most common brain tumor in adults. The study, published in Nature Genetics, reveals how the tumor's surrounding environment influences its behavior and patient outcomes. Led by neurosurgeon Gelareh Zadeh>>> of Mayo Clinic, the research utilized single-cell sequencing and spatial transcriptomics to analyze over 500,000 individual cells, creating a high-resolution 'atlas' of genetic footprints. This breakthrough offers clues to why some meningiomas are aggressive while others are benign, potentially leading to more precise risk prediction, personalized treatment decisions, and noninvasive monitoring through blood-based biomarkers. The findings also highlight potential therapeutic targets by identifying communication pathways between immune and tumor cells.