UK CAR T-cell Lupus Remission

Patients in the United Kingdom>>> with severe lupus have achieved remission following a groundbreaking 'immune reset' treatment on the United Kingdom — National Health Service>>> using CAR T-cell therapy. This marks the first time this therapy, previously used for cancer, has been applied to lupus in the UK. The trial, led by University College London Hospitals NHS Foundation Trust and University College London, saw five out of six patients go into remission within months, with rapid improvements in disease markers and kidney function. The CAR-T therapy, obecabtagene autoleucel (obe-cel), was developed by University College London spinout firm Autolus Therapeutics>>>. Experts like Karl Peggs>>> and Claire Roddie>>> believe this single-dose treatment could offer a cure for lupus and potentially other autoimmune diseases like multiple sclerosis, removing the need for lifelong medication. Patient Katie Tinkler>>>'s personal story highlights the transformative impact of the treatment.