LASSS enhances HGF for muscle repair
Analysis based on 16 articles · First reported Jul 24, 2026 · Last updated Jul 24, 2026
This early-stage research is unlikely to have immediate market impact. However, it could spur interest in trisulfide-based therapeutics for muscle regeneration, potentially benefiting biotechnology and pharmaceutical companies focused on aging and muscle disorders.
Researchers at Kyushu University, led by Professor Ryuichi Tatsumi, have identified that lipoic acid trisulfide (LASSS) can enhance hepatocyte growth factor (HGF) by more than doubling its binding affinity to c-met receptors and protecting it from nitration-induced dysfunction. The findings were published on July 24, 2026, in Scientific Reports. In a mouse model of muscle atrophy, LASSS pretreatment significantly reduced HGF nitration. The discovery may lead to new treatments for age-related muscle wasting and other conditions involving muscle disuse.
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