South Africa & United States — United States Agency for International Development

South Africa: South Africa hosts the Phalaborwa project, the largest recipient of DFC funding, which could boost its mining sector and strategic importance.

United States — United States Agency for International Development: The DFC is the primary actor, committing $62.8 million to African rare-earth projects to de-risk them and attract private investment, aligning with U.S. strategic goals.

South Africa: Deputy Health Minister Phaahla called for stronger domestic HIV financing in Africa.

United States — United States Agency for International Development: USAID's dismantling by the Trump administration directly impaired PEPFAR operations, as it managed many of the grants. The agency's role in global health has been diminished.

South Africa: Selected for generic production of lenacapavir, potentially boosting local pharmaceutical industry and access to HIV drugs.

United States — United States Agency for International Development: Dismantled by Trump administration, leading to funding cuts that severely affected global health programs including Joint United Nations Programme on HIV/AIDS.

South Africa: South Africa's President, Cyril Ramaphosa, is the African Union Champion for Pandemic Preparedness, Prevention and Response and was consulted on the PHECS declaration.

United States — United States Agency for International Development: The United States — United States Agency for International Development experienced severe budget cuts and layoffs under Donald Trump's administration, leading to a diminished capacity to respond to health crises like the Ebola outbreak in affected countries.

United States — United States Agency for International Development: The United States — United States Agency for International Development, previously a key provider of PPE and logistics, was dismantled, leading to a significant gap in the current Ebola response.